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- bs-14099P
- 2025年10月16日
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500ug
| 产品编号 | bs-14099P |
| 英文名称 | CTDSP2 Antibody Blocking Peptide |
| 中文名称 | 羧基端小结构域磷酸酶2封闭多肽 |
| 英文别名 | Carboxy terminal domain RNA polymerase II polypeptide A small phosphatase 2; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2; CTDS2_HUMAN; Ctdsp2; NIF2; NLI interacting factor 2; NLI-interacting factor 2; Nuclear LIM interactor interacting factor 2; Nuclear LIM interactor-interacting factor 2; OS4; Protein OS 4; Protein OS-4; PSR2; SCP2; Small C-terminal domain phosphatase 2; Small CTD phosphatase 2. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Tumor biomarkers > Enzymes > Phosphatases Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Co-activators/co-repressors Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Corticoid Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Testosterone Epigenetics and Nuclear Signaling > Transcription > Other factors Signal Transduction > Signaling Pathway > Nuclear Signaling > Nuclear Hormone Receptors > Co-activators/co-repressors Signal Transduction > Signaling Pathway > Nuclear Signaling > Nuclear Hormone Receptors > Corticoid Signal Transduction > Signaling Pathway > Nuclear Signaling > Nuclear Hormone Receptors > Testosterone |
| 亚基 | Monomer (By similarity). Interacts with REST. |
| 亚细胞定位 | Nucleus (By similarity). |
| 组织特异性 | Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver. |
| 相似性 | Contains 1 FCP1 homology domain. |
| 功能 | Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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