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- Bioss
- bs-0416P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-0416P |
| 英文名称 | TIMP-2 Antibody Blocking Peptide |
| 中文名称 | 金属蛋白酶组织抑制因子-2封闭多肽 |
| 英文别名 | Metalloproteinase inhibitor 2 precursor; Tissue inhibitor of metalloproteinases 2; Collagenase inhibitor; CSC 21K; CSC21K; TIMP2; TIMP 2; TIMP 2; TIMP metallopeptidase inhibitor 2; TIMP2_HUMAN; Metalloproteinase inhibitor 2; CSC-21K; TIMP-2. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Invasion/microenvironment > Angiogenesis > ECM enzymes > TIMPs Cancer > Invasion/microenvironment > ECM > Extracellular matrix > TIMPs Cardiovascular > Angiogenesis > Adhesion / ECM > Matrix Metalloproteinases > TIMP Cardiovascular > Atherosclerosis > Thrombosis > Endothelial mediators/regulators Cell Biology > Proteolysis / Ubiquitin > Protease inhibitors > Metalloprotease inhibitors > TIMPs Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Enzymes > MMP Inhibitors |
| 亚基 | Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity. |
| 亚细胞定位 | Secreted. |
| 翻译后修饰 | The activity of TIMP2 is dependent on the presence of disulfide bonds. |
| 相似性 | Belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain. |
| 功能 | Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]. |
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TIMP-2 Antibody Blocking Peptide(bs-0416P)-500ug
￥880
