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- bs-11575P
- 2025年10月16日
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500ug
| 产品编号 | bs-11575P |
| 英文名称 | PDE7A Antibody Blocking Peptide |
| 中文名称 | 磷酸二酯酶7封闭多肽 |
| 英文别名 | HCP 1; HCP1; High affinity cAMP specific 3'5' cyclic phosphodiesterase 7A; High affinity cAMP-specific 3''; P2A; PDE 7; PDE 7A; PDE7; PDE71; PDE7A; PDE7A_HUMAN; Phosphodiesterase 7A; Phosphodiesterase isozyme 7; Phosphodiesterase7A; Rolipram insensitive phosphodiesterase type 7; TM 22; TM22; 5''-cyclic phosphodiesterase 7A. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Neural Signal Transduction Signal Transduction > Second Messenger > Nucleotide Messenger > cAMP |
| 亚基 | Interacts with CBFA2T3. |
| 亚细胞定位 | Cytoplasm |
| 组织特异性 | PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart. |
| 相似性 | Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily. |
| 功能 | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Phosphodiesterases (PDE, also designated cyclic nucleotide phosphodiesterase) are important for the downregulation of the intracellular level of the second messenger cyclic adenosine monophosphate (cAMP) by hydrolyzing cAMP to 5'AMP. Phosphodiesterase type 3 isoforms, PDE3A and 3B, are expressed primarily in cardiovascular tissue and adipose tissue, respectively. PDE3A, is found in myocardium and platelets and PDE3B is found in lymphocytes. The PDE7A1 (HCP1) isozyme and the PDE7A2 proteins, alternate splice products of PDE7A, are highly expressed in skeletal muscle. PDE7B is most highly expressed in pancreas. The PDE family contains proteins that serve tissue-specific roles in regulation of lipolysis, glycogenolysis, myocardial contractility, and smooth muscle relaxation. |
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PDE7A Antibody Blocking Peptide(bs-11575P)-500ug
￥880
