HABP4 Antibody Blocking Peptide(bs-15402P)-500ug

HABP4 Antibody Blocking Peptid

e(bs-15402P)-500ug
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  • ¥880
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  • bs-15402P
  • 2025年10月16日
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      500ug

    产品编号bs-15402P
    英文名称HABP4 Antibody Blocking Peptide
    中文名称透明质酸结合蛋白4封闭多肽
    英文别名IHABP-4; IHABP4; Intracellular hyaluronan-binding protein 4; Ki-1/57 intracellular antigen; HABP4_HUMAN.
    纯化方法HPLC
    亚基Interacts with the C-terminus of CHD3. Interacts via its C-terminal region with GNB2L1. Interacts with p53/TP53.
    亚细胞定位Cytoplasm. Nucleus. Note=Transported into the nuclear compartment in activated leukocytes.
    组织特异性Highly expressed in brain, heart, and kidney, and moderately expressed in skeletal muscle. Also expressed in a variety of tumor cell lines and in activated but not resting leukocytes.
    翻译后修饰Phosphorylated by phorbol 12-myristate 13-acetate (PMA)-activated PKC isoforms at Thr-354 and Thr-375 (Probable).
    功能May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription.
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料The intracellular hyaluronan-binding protein 4 is a cytoplasmic and nuclear protein that is phosphorylated on serine and threonine residues. HABP4 is expressed as a protein of 413 amino acids and is phosphorylated by phorbol 12-myristate 13-acetate (PMA)-activated PKC isoforms at Thr-354 and Thr-375. HABP4 interacts with hyaluron, the adaptor protein RACK1, the transcription factor MEF2C and the chromatin remodeling factor CHD3, suggesting that it may be involved in the regulation of transcription. However, its actual function has yet to be elucidated. HABP4 is highly expressed in brain, heart, and kidney and is moderately expressed in skeletal muscle. Also, HABP4 is expressed in a variety of tumor cell lines and in activated, but not resting, leukocytes.

     

     

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