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- Bioss
- bs-11543P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-11543P |
| 英文名称 | ADAP1 Antibody Blocking Peptide |
| 中文名称 | Centaurin α1封闭多肽 |
| 英文别名 | ArfGAP with dual PH domains 1; CENTA 1; CENTA1; Centaurin alpha; GCS1L; IP4/PIP3 binding protein; p42IP4; Putative MAPK activating protein PM25; ADAP1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Neural Signal Transduction Signal Transduction > Adapters > Cytoplasmic Signal Transduction > Signaling Pathway > Lipid Signaling |
| 亚基 | Interacts with PRKCA, PRKCI and PRKCZ. Interacts with the N-terminal region of PRKD1. |
| 亚细胞定位 | Cellular localizationCytoplasmic, Nuclear and Plasma membrane |
| 组织特异性 | Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes. |
| 翻译后修饰 | Phosphorylated by PRKCA, PRKCI, PRKCZ and PRKD1 in vitro. |
| 相似性 | Contains 1 Arf-GAP domain. Contains 2 PH domains. |
| 功能 | The centaurin alpha 1 protein is a high affinity PtdIns(3,4,5)P3 binding protein enriched in brain. By acting as a GTPase activating protein for ADP ribosylation factor 6 (ARF6), centaurin alpha 1 is able to switch off ARF6 and inhibit its ability to mediate beta 2 adrenoceptor internalization and negatively regulates ARF6 activity by functioning as an in vivo PIP3 dependent ARF6 GAP. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | ADP-ribosylation factor (ARF) family of small GTP-binding proteins are involved in vesicular transport regulation and in controlling cytoskeletal organization and cell adhesion. These proteins are best characterized as regulators of membrane traffic. The Centaurin GTPase-activating protein family comprise a subset of ARF regulatory molecules that transduce PI 3-kinase activation into coordinated control of Arf-dependent pathways. This family includes ASAP1, ACAP1, ACAP2, AGAP1, ARAP1, ARAP2, Centaurin a1 and Centaurin g3. The Centaurin a1 protein is a high affinity PtdIns(3,4,5)P3 binding protein enriched in brain. By acting as a GTPase activating protein for ADP ribosylation factor 6 (ARF6), Centaurin a1 is able to switch off ARF6 and inhibit its ability to mediate b2-adrenoceptor internalization and negatively regulate ARF6 activity by functioning as an in vivo PIP3 dependent ARF6 GAP. |
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ADAP1 Antibody Blocking Peptide(bs-11543P)-500ug
￥880
