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- Bioss
- bs-11537P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11537P |
| 英文名称 | CBLN3/Cerebellin 3 Antibody Blocking Peptide |
| 中文名称 | 小脑肽3封闭多肽 |
| 英文别名 | Cbln3; Cbln 3; Cbln-3; CBLN3_HUMAN; Cerebellin-3; Cerebellin3; Cerebellin 3; PRO1486. |
| 纯化方法 | HPLC |
| 亚基 | Heterohexamer; disulfide-linked heterotrimers. Does not homooligomerize, but probably forms a complex with at least CBLN1. May interact with CBLN2 and CBLN4 |
| 亚细胞定位 | Secreted. Cell junction, synapse (By similarity). Note=Secretion depends probably on a association with CBLN1 or perhaps CBLN4 but not on CBLN2 |
| 相似性 | Contains 1 C1q domain. |
| 功能 | May be involved in synaptic functions in the CNS. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor called Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3) and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. Cerebellin and its metabolite, des-Ser(1)Cer, are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric complexes, thereby influencing each other’s degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of Cerebellin have been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for Cerebellin in the pathology of these diseases. |
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CBLN3/Cerebellin 3 Antibody Blocking Peptide(bs-11537P)-500ug
￥880
