CROP Antibody Blocking Peptide(bs-14067P)-500ug

CROP Antibody Blocking Peptide

(bs-14067P)-500ug
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  • bs-14067P
  • 2025年10月16日
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      500ug

    产品编号bs-14067P
    英文名称CROP Antibody Blocking Peptide
    中文名称环磷酸腺苷调节元件相关蛋白1封闭多肽
    英文别名cAMP regulatory element-associated protein 1; Cisplatin resistance-associated overexpressed protein; Cisplatin resistance-associated-overexpressed protein; CRE-associated protein 1; CREAP-1; CREAP1; CROP; LC7L3_HUMAN; Luc7-like protein 3; Luc7A; LUC7L3; O48; Okadaic acid-inducible phosphoprotein OA48-18.
    纯化方法HPLC
    研究领域

    Epigenetics and Nuclear Signaling > DNA / RNA > DNA Damage & Repair > DNA Damage Response > ATM / ATR

    Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing > Splicing

    亚细胞定位Nucleus speckle. The subnuclear localization is affected by cisplatin.
    组织特异性Widely expressed. Highest levels in heart, brain, pancreas, thymus, ovary, small intestine and peripheral blood leukocytes, as well as cerebellum, putamen and pituitary gland. Lowest levels in lung, liver and kidney. Also expressed in fetal tissues, including brain, heart, kidney, thymus and lung.
    翻译后修饰Phosphorylated in vitro by SRPK1, SRPK2 and CLK1. Phosphorylated upon DNA damage, probably by ATM or ATR.
    相似性Belongs to the Luc7 family.
    功能Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing.
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2009]

     

     

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