- ￥880
- Bioss
- bs-15370P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-15370P |
| 英文名称 | GPCR MRGX2 Antibody Blocking Peptide |
| 中文名称 | G蛋白偶联受体MRGX2蛋白封闭多肽 |
| 英文别名 | Mas-related G-protein coupled receptor member X2; MRGPRX2; MRGX2; MRGX2_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurotransmission > Receptors / Channels > GPCR > More GPCR Neuroscience > Sensory System > Somatosensory system > Nociception Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. Mas subfamily. |
| 功能 | Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Mas-related G protein-coupled receptor member X1 (MRGX) is a sensory neuron-specific G protein-coupled receptor that is involved in the development and function of nociceptive neurons and may also regulate the sensation or modulation of pain. MRGPRX2, is a 330 amino acid multi-pass membrane protein that functions as an orphan receptor and, like MRGX, is thought to be involved in the function of nociceptive neurons. Expressed in the central nervous system with highest expression in dorsal root ganglia, MRGX2 may also be involved in cortistatin function, possibly playing a role in sleep regulation and cortical function. |
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GPCR MRGX2 Antibody Blocking Peptide(bs-15370P)-500ug
￥880
