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- Bioss
- bs-1214P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-1214P |
| 英文名称 | TNFSF10 Antibody Blocking Peptide |
| 中文名称 | 肿瘤坏死因子相关凋亡诱导配体封闭多肽 |
| 英文别名 | APO2L; TNFSF10; Apo 2 ligand; Apo 2L; CD 253; CD253; CD253 antigen; Protein TRAIL; TL 2; TL2; TNF Related Apoptosis Inducing Ligand; TNF related apoptosis inducing ligand TRAIL; TNFSF 10; TNFSF10 protein; TRAIL; TRAIL PEN; Tumor Necrosis Factor (ligand) Superfamily Member 10; TNF10_HUMAN. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell Death > Apoptosis > Receptors > Death receptors & ligands > TRAIL Cancer > Invasion/microenvironment > Apoptosis > Death receptors & ligands > TRAIL Cardiovascular > Atherosclerosis > Apoptosis Cell Biology > Apoptosis > Extracellular Signals > Death Ligands |
| 亚基 | Homotrimer. |
| 亚细胞定位 | Membrane; Single-pass type II membrane protein (Potential). |
| 组织特异性 | Widespread; most predominant in spleen, lung and prostate. |
| 相似性 | Belongs to the tumor necrosis factor family. |
| 功能 | Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3.(tumor necrosis factor-related apoptosis-inducing ligand) |
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TNFSF10 Antibody Blocking Peptide(bs-1214P)-500ug
￥880
