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- Bioss
- bs-11474P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-11474P |
| 英文名称 | RGMB Antibody Blocking Peptide |
| 中文名称 | 反义导向分子RGMB封闭多肽 |
| 英文别名 | RGMB; Dragon; DRG11-responsive axonal guidance and outgrowth of neurite; Repulsive Guidance Molecule B; RGM b; RGM domain family member B; Rgmb; RGMB_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Neurogenesis Stem Cells > Signaling Pathways > TGF beta > Surface Molecules |
| 亚基 | Homooligomer (By similarity). Interacts with DRGX (By similarity). Interacts with BMP2 and BMP4 (By similarity). Interacts with the BMP type I receptors ACVR1, BMPR1A and BMPR1B and with the BMP type II receptor ACVR2B |
| 亚细胞定位 | Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Membrane raft |
| 翻译后修饰 | GPI-anchored. |
| 相似性 | Belongs to the repulsive guidance molecule (RGM) family. |
| 功能 | Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The repulsive guidance molecule (RGM) family of proteins are important in the guidance of growth cones of developing neurons. They are repulsive for a group of axons, those from the temporal half of the retina. RGM have been implicated in both axonal guidance and neural tube closure but as opposed to for ephrins, semaphorins, netrins and slits, no receptor mechanism for RGM activation has been defined. Dorsal root ganglion axons do not respond to RGM but neogenin (a netrin-binding protein which can function as an RGM receptor) expression can spur RGM responsiveness. The RGM proteins are attached to the membrane by a GPI-anchor. Two members of this family, RGMa and RGMb, are expressed in the nervous system. RGMc, also known as Hemojuvelin, is a part of the signaling pathway activating hepcidin and works together with hepcidin to restrict iron absorption in the gut. Defects in the gene encoding for RGMc causes the autosomal recessive disorder juvenile hemochromatosis (JH). |
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RGMB Antibody Blocking Peptide(bs-11474P)-500ug
￥880
