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- Bioss
- bs-1680P
- 2025年10月16日
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500ug
| 产品编号 | bs-1680P |
| 英文名称 | CDK3 Antibody Blocking Peptide |
| 中文名称 | 周期素依赖性激酶3封闭多肽 |
| 英文别名 | Cdk 3; Cell division kinase 3; Cell division protein kinase 3; Cyclin dependent kinase 3; p36; Cdk3; CDK3_HUMAN; CDKN3; Cell division protein kinase 3; Cyclin dependent kinase 3; Cyclin-dependent kinase 3; OTTHUMP00000206828; p36. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Cell Cycle > Kinases/Phosphatases > Cdks Epigenetics and Nuclear Signaling > Cell cycle > Kinases/Phosphatases > Cdks |
| 亚基 | Interacts with CABLES1 and CABLES2. Interacts with ATF1. Binding to CCNC/cyclin-C promotes RB1 phosphorylation. |
| 组织特异性 | Expressed in cancer cell lines and glioblastoma tissue. |
| 相似性 | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain. |
| 功能 | Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008] |
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CDK3 Antibody Blocking Peptide(bs-1680P)-500ug
￥880
