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- bs-43568P
- 2025年10月16日
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- 规格：
100ug/500ug/20ug
| 规格： | 100ug | 产品价格： | ￥2280.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥6880.0 |
| 规格： | 20ug | 产品价格： | ￥680.0 |
| 产品编号 | bs-43568P |
| 英文名称 | Recombinant human GPR37 protein, C-His (HEK293) |
| 中文名称 | 重组人G蛋白偶联受体37蛋白 |
| 英文别名 | GPCR GPR37; EDNRBL; Endothelin B receptor like protein 1; Endothelin B receptor-like protein 1; Endothelin receptor type B like; ETBR LP 1; ETBR-LP-1; ETBRLP1; G protein coupled receptor 37; G protein coupled receptor 37 endothelin receptor type B like; Gpr37; GPR37_HUMAN; hET(B)R LP; hET(B)RLP; PAELR; Parkin associated endothelin receptor like receptor; Parkin-associated endothelin receptor-like receptor; Probable G protein coupled receptor 37; Probable G-protein coupled receptor 37; GPCR 37. |
| 性状 | Lyophilized or Liqui |
| 纯化方法 | AC |
| 理论分子量 | 26.3 |
| 浓度 | >1mg/ml |
| 储存液 | PBS (pH7.4). |
| 研究领域 | Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR |
| 亚基 | Forms a complex with PARK2, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating PARK2-mediated GPR37 ubiquitination. Interacts with PACRG. |
| 亚细胞定位 | Cell membrane. Endoplasmic reticulum membrane. |
| 组织特异性 | Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ). |
| 翻译后修饰 | Ubiquitinated by PARK2 in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. |
| 功能 | Orphan receptor. May have a unique functional role in the central nervous system. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Pael receptor (Pael-R), also known as Parkin-associated endothelin receptor-like receptor, is a putative G protein-coupled transmembrane polypeptide. The gene that encodes Pael-R maps to chromosome 7q31. Pael-R belongs to family 1 of the G protein-coupled receptors and is mainly expressed in the brain. Pael-R interacts with Parkin, the gene product responsible for familial Parkinson’s disease. |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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Recombinant human GPR37 protein, C-His (HEK293)(bs-43568P)-100ug/500ug/20ug
￥680 - 6880
