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- Bioss
- bs-11446P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11446P |
| 英文名称 | ARNTL2 Antibody Blocking Peptide |
| 中文名称 | 芳香烃受体核转录蛋白样2封闭多肽 |
| 英文别名 | ARNT L2; ARNTL 2; ARNTL2; ARNTL2 protein; Aryl hydrocarbon receptor nuclear translocator like 2; Aryl hydrocarbon receptor nuclear translocator like protein 2; Aryl hydrocarbon receptor nuclear translocator-like 2; Basic helix loop helix PAS protein MOP9; Basic-helix-loop-helix-PAS protein MOP9; bHLHe6; BMA L2; BMAL 2; BMAL2; Brain and muscle ARNT like 2; Brain and muscle ARNT-like 2; CLIF; CYCLE like factor; CYCLE-like factor; Member of PAS protein 9; MGC124257; MGC149671; MGC149672; MGC158186; MOP 9; MOP9; PASD 9; PASD9; Transcription factor BMAL 2; Transcription factor BMAL2; wu:fj90c09; BMAL2_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Heart > Cardiac metabolism Cardiovascular > Heart > Cardiogenesis > Transcription factors/regulators Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper > HLH Epigenetics and Nuclear Signaling > Transcription > Transcription Factors Neuroscience > Neurology process > Circadian Rhythm > Receptors |
| 亚基 | Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with CLOCK to form the ARNTL2-CLOCK transactivator. Can form heterodimers or homodimers which interact directly with CLOCK to form the transcription activator. Also interacts with NPAS2 and HIF1A. |
| 亚细胞定位 | Nuclear |
| 组织特异性 | Expressed in fetal brain. Highly expressed in brain and placenta. Lower levels in heart, liver, thymus, kidney and lung. Located to endothelial cells and neuronal cells of the suprachiasmatic nucleus (SCN). Also detected in endothelial cells of the heart, lung and kidney. In the brain, specifically expressed in the thalamus, hippocampus and amygdala. |
| 相似性 | Contains 1 bHLH (basic helix-loop-helix) domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 2 PAS (PER-ARNT-SIM) domains. |
| 功能 | ARNTL2 (aryl hydrocarbon receptor nuclear translocator-like 2) is a basic Helix-Loop-Helix-Per-Arnt-Sim (bHLH-PAS) transcription factor. ARNTL2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription. Also, in umbilical vein endothelial cells, ARNTL2 activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1. It may participate in circadian clock regulation |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | BMAL2 is a 636 amino acid protein that localizes to the nucleus and contains one bHLH (basic helix-loop-helix) domain, one PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains. Expressed at high levels in placenta and brain and at lower levels in liver, thymus, heart, lung and kidney, BMAL2 functions as a component of the circadian core oscillator, which includes a variety of proteins that work in tandem to activate the transcription of target genes. More specifically, BMAL2, when functioning as a component of the core oscillator, binds to the E-box element (3'-CACGTG-5') of target DNA, thus inducing transcription. Multiple isoforms of BMAL2 exist due to alternative splicing events. |
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ARNTL2 Antibody Blocking Peptide(bs-11446P)-500ug
￥880
