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- bs-11450P
- 2025年10月16日
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500ug
| 产品编号 | bs-11450P |
| 英文名称 | AMIGO2 Antibody Blocking Peptide |
| 中文名称 | 粘附分子IgG样结构域蛋白2封闭多肽 |
| 英文别名 | Adhesion molecule with Ig like domain 2; ALI 1; ALI1; Alivin 1; Alivin-1; Alivin1; AMIGO 2; Amphoterin induced gene 2; Amphoterin induced protein 2; DEGA; AMGO2_HUMAN; AMIGO-2; Amigo2; Amphoterin induced protein 2; Amphoterin-induced protein 2; Differentially expressed in gastric adenocarcinoma; Differentially expressed in gastric adenocarcinomas; Transmembrane protein AMIGO 2; Transmembrane protein AMIGO2. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Growth and Development > Axonal Guidance Proteins |
| 亚基 | Binds itself as well as AMIGO1 and AMIGO3 (By similarity). |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. Nucleus. Note: Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons By |
| 组织特异性 | Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers. |
| 相似性 | Belongs to the immunoglobulin superfamily. AMIGO family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 6 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. |
| 功能 | A novel primary response gene, AMIGO2, is an activity-dependent gene and promotes survival of neurons. Sequence analyses reveal that rat, mouse, and human AMIGO2 proteins contain seven leucine-rich repeats, one IgC2-like loop and a transmembrane domain, and display homology to Kek and Trk families. Results suggest that expression of ali1 promotes depolarization-dependent survival of the granule neuron. Mouse AMIGO2 was mapped to a locus approximately 55.3 cm from the centromere on chromosome 15 that is syntenic to positional candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The amphoterin-induced gene and ORF (AMIGO) family of proteins consists of AMIGO-1, AMIGO-2 and AMIGO-3. All three members are single pass type I membrane proteins that contain several leucine-rich repeats, one IgG domain, and a transmembrane domain. The AMIGO proteins are specifically expressed on fiber tracts of neuronal tissues and participate in their formation. The AMIGO proteins can form complexes with each other, but can also bind itself. AMIGO-1, also designated Alivin-2, promotes growth and fasciculation of neurites and plays a role in myelination and fasciculation of developing neural axons. In cerebellar neurons, AMIGO-2 (Alivin-1) is crucial for depolarization-dependent survival. Similar to AMIGO-1 and AMIGO-2, AMIGO-3 (Alivin-3) plays a role in homophilic and/or heterophilic cell-cell interaction and signal transduction. |
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AMIGO2 Antibody Blocking Peptide(bs-11450P)-500ug
￥880
