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- Bioss
- bs-2438P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-2438P |
| 英文名称 | AVEN Antibody Blocking Peptide |
| 中文名称 | 细胞死亡调节剂Aven抗体 |
| 英文别名 | AVEN_HUMAN; Cell death regulator Aven; apoptosis and caspase activation inhibitor; PDCD12; |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Tumor biomarkers Cell Biology > Apoptosis > Intracellular > Associated Proteins Cell Biology > Apoptosis > Intracellular > Caspases etc > Inhibitors |
| 亚基 | Binds Apaf-1, BCL-2 and BAD (Bcl-xl) |
| 亚细胞定位 | Endomembrane system; Peripheral membrane protein. Note=Associated with intracellular membranes. |
| 组织特异性 | Highly expressed in testis, ovary, thymus, prostate, spleen, small intestine, colon, heart, skeletal muscle, liver, kidney and pancreas. |
| 功能 | Protects against apoptosis mediated by Apaf-1 |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. AVEN is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that AVEN functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that AVEN impedes Apaf-1-mediated caspase activation. Higher levels of AVEN mRNA are seen in patients with acute leukemia than in control patients, suggesting that AVEN may be useful as a prognostic indicator in leukemia patients. |
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AVEN Antibody Blocking Peptide(bs-2438P)-500ug
￥880
