- ￥880
- Bioss
- bs-16801P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-16801P |
| 英文名称 | KPC2 Antibody Blocking Peptide |
| 中文名称 | E3泛素蛋白连接酶亚基KPC2封闭多肽 |
| 英文别名 | UBAC1_HUMAN; Ubiquitin-associated domain-containing protein 1; UBA domain-containing protein 1; E3 ubiquitin-protein ligase subunit KPC2; Glialblastoma cell differentiation-related protein 1; Kip1 ubiquitination-promoting complex protein 2. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ub-like Proteins |
| 亚基 | Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts with RNF123 via its N-terminal domain. Interacts with the proteasome via its N-terminal domain. |
| 亚细胞定位 | Cytoplasmic |
| 相似性 | Ubiquitous. Contains 1 STI1 domain. Contains 2 UBA domains. Contains 1 ubiquitin-like domain. |
| 功能 | Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | KPC2 (Kip1 ubiquitylation-promoting complex 2) together with KPC1 forms the ubiquitin ligase KPC, which regulates degradation of the cyclin-dependent kinase inhibitor p27 at the G1 phase of the cell cycle. KPC2 contains a ubiquitin-like (UBL) domain, two ubiquitin-associated (UBA) domains, and a heat shock chaperonin-binding (STI1) domain. |
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KPC2 Antibody Blocking Peptide(bs-16801P)-500ug
￥880
