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- Bioss
- bs-10794P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-10794P |
| 英文名称 | Sox3 Antibody Blocking Peptide |
| 中文名称 | 转录因子Sox3封闭多肽 |
| 英文别名 | Sox-3; GHDX; Infundibular hypoplasia and hypopituitarism; MRGH; PHP; SOXB; SRY Box 3; SRY related HMG box gene 3; SRY Sex Determining Region Y Box 3; Transcription factor SOX-3; SOX3_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Domain Families > HMG Box Neuroscience > Endocrine system > Hypothalamic pituitary adrenal axis Neuroscience > Neurology process > Neural Signal Transduction |
| 亚基 | Interacts with SOX2 and FGFR1 |
| 亚细胞定位 | Nuclear. |
| 相似性 | Contains 1 HMG box DNA-binding domain. |
| 功能 | SOX 3 is also known as SRY related HMG BOX gene 3. All SOX proteins have a single HMG box. Humans with mutations in SOX3 have panhypopituitarism. Conditional disruption of SOX3 in mice demonstrates that anterior pituitary development depends on SOX3 expression in the overlying neural ectoderm. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal. Sox-3, also known as MRGH or SOXB, is implicated in mental retardation X-linked with isolated growth hormone deficiency (MRXGH) and infundibular hypoplasia and hypopituitarism. |
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Sox3 Antibody Blocking Peptide(bs-10794P)-500ug
￥880
