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- bs-16790P
- 2025年10月16日
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500ug
| 产品编号 | bs-16790P |
| 英文名称 | KMT2A Antibody Blocking Peptide |
| 中文名称 | 急性淋巴细胞性白血病1封闭多肽 |
| 英文别名 | Acute lymphocytic leukemia 1; ALL 1; ALL-1; ALL1; C-terminal cleavage product of 180 kDa; CXXC 7; CXXC-type zinc finger protein 7; CXXC7; HRX; HTRX 1; HTRX1; KMT2A; Lysine N-methyltransferase 2A; MLL 1A; Mll; MLL cleavage product C180; MLL1; MLL1_HUMAN; MLL1A; Myeloid/lymphoid or mixed lineage leukemia; N-terminal cleavage product of 320 kDa; p180; p320; Trithorax homolog; Trithorax homolog Drosophila; Trithorax like protein; Trithorax-like protein; TRX 1; TRX1; Zinc finger protein HRX. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Nucleus and Nucleus. Localizes to a diffuse nuclear pattern when not associated with MLL cleavage product N320. |
| 组织特异性 | Heart, lung, brain and T- and B-lymphocytes. |
| 翻译后修饰 | Proteolytic cleavage by TASP1 generates MLL cleavage product N320 and MLL cleavage product C180, which reassemble through a non-covalent association. 2 cleavage sites exist, cleavage site 1 (CS1) and cleavage site 2 (CS2), to generate MLL cleavage products N320 and C180. CS2 is the major site. |
| 相似性 | Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. Contains 3 A.T hook DNA-binding domains. Contains 1 bromo domain. Contains 1 CXXC-type zinc finger. Contains 1 FY-rich C-terminal domain. Contains 1 FY-rich N-terminal domain. Contains 3 PHD-type zinc fingers. Contains 1 post-SET domain. Contains 1 SET domain. |
| 功能 | Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010] |
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KMT2A Antibody Blocking Peptide(bs-16790P)-500ug
￥880
