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- 2025年10月16日
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500ug
| 产品编号 | bs-11431P |
| 英文名称 | DUOX1 Antibody Blocking Peptide |
| 中文名称 | 双氧化酶1/甲状腺氧化酶1封闭多肽 |
| 英文别名 | Dual oxidase 1; Dual oxidase 1 precursor; DUOX1; EC 1.11.1; EC 1.6.3.1; Flavoprotein NADPH oxidase; Large NOX 1; LNOX1; Long NOX 1; MGC138840; MGC138841; NADPH thyroid oxidase 1; Nicotinamide adenine dinucleotide phosphate oxidase; NOXEF1; THOX1; Thyroid oxidase 1; DUOX1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Energy Metabolism Neuroscience > Endocrine system > Thyroid axis Signal Transduction > Growth Factors/Hormones > Hormones Signal Transduction > Metabolism > Energy Metabolism |
| 亚基 | Interacts with TXNDC11, TPO and CYBA. |
| 亚细胞定位 | Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane of epithelial cells. |
| 组织特异性 | Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart. |
| 翻译后修饰 | N-glycosylated. |
| 相似性 | In the N-terminal section; belongs to the peroxidase family. Contains 3 EF-hand domains. Contains 1 FAD-binding FR-type domain. Contains 1 ferric oxidoreductase domain. |
| 功能 | The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX2. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. Two alternatively spliced transcript variants encoding the same protein have been described for this gene (from EntrezGene). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Dual oxidase 1 (DUOX1), a homolog of glycoprotein p91Phox, is expressed in airway epithelium and generates reactive oxygen species (ROS). DUOX1 is a multi-pass membrane protein predominantly expressed in thyrocytes and tracheal surface epithelial cells, as well as thyroid, trachea and bronchium. DUOX1 generates hydrogen peroxide, which is crucial for thyroid peroxidase and lactoperoxidase. It is also involved in thyroid hormone synthesis and lactoperoxidase-mediated antimicrobial defense in mucosa. DUOX1, which also plays a role in mucin expression, is widely expressed in fetal tissues. |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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