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- Bioss
- bs-1528P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-1528P |
| 英文名称 | ATRN Antibody Blocking Peptide |
| 中文名称 | 吸引素封闭多肽 |
| 英文别名 | ATRN; Attractin; DPPT-L; KIAA0548; Mahogany homolog; mahogany protein; MGCA. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Metabolism |
| 亚基 | Monomer and homotrimer. |
| 亚细胞定位 | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Secreted. |
| 组织特异性 | Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes. |
| 翻译后修饰 | Heavily glycosylated. |
| 相似性 | Contains 1 C-type lectin domain. Contains 1 CUB domain. Contains 1 EGF-like domain. Contains 6 Kelch repeats. Contains 2 laminin EGF-like domains. Contains 4 PSI domains. |
| 功能 | Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Attractin is a serum glycoprotein of 175 kDaand found in both membrane-bound and secreted forms as a result of alternative splicing. Both the secreted and membrane-bound forms of attractin may be involved in the development and maintenance of the central nervous system. Membrane-bound attractin is a co-receptor for Agouti, antagonist of melanocortin-1 receptor. Secreted attractin, expressed by activated T lymphocytes and modulates interactions between T cells and monocytes/macrophages, was examined as a potential marker of immune activity. Attractinmay be a component of a pathway for regulated protein turnover that also involves mahogunin, a wide-expressed E3 ubiquitinligase found at particularly high levels in the brain. Attractinwas considered as an extracellular target amenable for the development of obesity-regulating drugs, also. |
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ATRN Antibody Blocking Peptide(bs-1528P)-500ug
￥880
