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- bs-13953P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-13953P |
| 英文名称 | CIITA Antibody Blocking Peptide |
| 中文名称 | 组织相容性复合体蛋白2反式激活因子封闭多肽 |
| 英文别名 | C2TA; C2TA_HUMAN; CIITA; Ciita; CIITA IV; class II major histocompatibility complex transactivator; class II transactivator; MHC class II transactivator; MHC class II transactivator type III; MHC2TA; NLR family acid domain containing; NLRA; Nucleotide binding oligomerization domain leucine rich repeat and acid domain containing. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Other factors Immunology > Adaptive Immunity > MHC > Class II |
| 亚基 | Interacts with ZXDA and ZXDC. Interacts with PML (isoform PML-2). |
| 亚细胞定位 | Nucleus. |
| 相似性 | Contains 4 LRR (leucine-rich) repeats. Contains 1 NACHT domain. |
| 功能 | Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq, Jul 2008] |
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CIITA Antibody Blocking Peptide(bs-13953P)-500ug
￥880
