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- 2025年10月16日
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| 产品编号 | bs-12707P |
| 英文名称 | cAMP-receptor protein Antibody Blocking Peptide |
| 中文名称 | 腺苷受体蛋白封闭多肽 |
| 英文别名 | CRP_ECOLI; cAMP-activated global transcriptional regulator CRP; Catabolite activator protein; CAP; Catabolite gene activator; cAMP receptor protein; CRP; cAMP regulatory protein. |
| 纯化方法 | HPLC |
| 研究领域 | Metabolism > Pathways and Processes > Cofactors, Vitamins / minerals > Vitamins / minerals Signal Transduction > Metabolism > Vitamins / Minerals |
| 亚基 | Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Found in plasma. |
| 相似性 | Belongs to the pentaxin family. Contains 1 pentaxin domain. |
| 功能 | Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers. |
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文献和实验Peptide Microarrays for Serum Antibody Diagnostics
Peptide microarrays are useful instruments for miniaturized high-throughput, high-content immunoassays. The substitution of linear epitopes of the protein antigen with short, synthetic peptides is virtually a straightforward approach
Antibody Epitope Mapping Using SPOT Peptide Arrays
types of peptide libraries and their applications are described: protein sequence-derived scans of overlapping peptides (peptide scans) used to locate epitopes within the protein sequence, truncation libraries used to identify the minimal peptide length
Blocking of unwanted non-specific staining
and other cell types. By exploiting the preferential avidity of Fc receptor for human > mouse Ig> rabbit > swine > goat immunoglubulins, one may use a blocking of the receptors with a reagent which will not interfere with the secondary reagents
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