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| 产品编号 | bs-0931P |
| 英文名称 | Histone H1.4 (Histone H1b) (AcLys53) Antibody Blocking Peptide |
| 中文名称 | 乙酰化组蛋白H1b封闭多肽 |
| 英文别名 | Histone H1.4(Ac-Lys53); Histone H1b (Ac-Lys53); Acetyl-Histone H1.4 (Lys53); Acetyl-Histone H1.4 (K53); HIST1H1E; H1F4; Histone H1.4; Histone H1b; H14_HUMAN; Histone H1s-4; H1 histone family member 4; H1E; Hist1h1e; Histone 1 H1e; Histone cluster 1 H1e; Histone H1; MGC116819. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Histones > H1 > Unmodified Epigenetics and Nuclear Signaling > Histones > Variants |
| 亚细胞定位 | Nucleus. Chromosome. |
| 翻译后修饰 | Acetylated at Lys-26. Deacetylated at Lys-26 by SIRT1. |
| 相似性 | Belongs to the histone H1/H5 family. Contains 1 H15 (linker histone H1/H5 globular) domain. |
| 功能 | Histones H1 are necessary for the condensation of nucleosome chains into higher order structures. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Histone H1b are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. |
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文献和实验activity measurements. Here we provide protocols for precipitation of fluorescent fusion proteins from crude cell extracts to identify and map protein–protein interactions as well as specific histone tail peptide binding in an easy and reliable manner.
Competing Chromosomal Proteins from Drosophila Polytene Chromosomes Using Modified Histone Peptides
al ., 1996). In this adaptation, I used differently methylated histone tail peptides to compete Polycomb protein from polytene chromosomes, finding that competition was peptide specific and locus-specific (Ringrose et al ., 2004). (I also tried RNAse
T cells and is important in cytotoxic T cell induced apoptosis, activating caspase independent pathways. Once in a cell, Granzyme A activates DNA nicking by the recently identified DNAse NM23-H1, a tumor suppressor gene product whose expression
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