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- bs-24311P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-24311P |
| 英文名称 | MX1 Antibody Blocking Peptide |
| 中文名称 | MX1封闭多肽 |
| 英文别名 | N-terminally processed; Human interferon regulated resistance GTP binding protein MXA; IFI 78; IFI 78K; IFI-78K; IFI78; IFI78K; Interferon induced GTP binding protein Mx1; Interferon induced protein p78; Interferon inducible protein p78; Interferon regulated resistance GTP binding protein; Interferon regulated resistance GTP binding protein MxA; Interferon-induced GTP-binding protein Mx1; Interferon-induced protein p78; Interferon-regulated resistance GTP-binding protein MxA; MX 1; MX; MX1; MX1_HUMAN; MxA; Myxoma resistance protein 1; Myxovirus (influenza virus) resistance 1 interferon inducible; Myxovirus (influenza virus) resistance 1 interferon inducible protein p78; Myxovirus (influenza) resistance 1 homolog of murine; Myxovirus resistance protein 1. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Immune System Diseases > Antiviral Signaling Microbiology > Interspecies Interaction > Host Virus Interaction |
| 亚基 | Homotetramer. |
| 亚细胞定位 | Secreted, extracellular space. Nucleus. Note=Translocates into the nuclei of HSV-1 infected cells. |
| 相似性 | Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. |
| 功能 | May regulate the calcium channel activity of TRPCs. Shows activity against influenza virus and VSV, a rhabdovirus. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | bs-6653P is one synthetic peptide derived from human MX1. The Dynamin family of microtubule-associated proteins function as GTPases that are involved in microtubule bundling and endocytosis. In mice, Mx2 (myxovirus resistance protein 2) and Mx1 (myxovirus resistance protein 1) are members of the Dynamin family that are involved in the immune response to viral infections. Localized to the cytoplasm, Mx2 contains one GED domain and is expressed in response to viral infection or treatment by IFN-alpha/IFN-beta. Once expression is induced, Mx2 accumulates in the cytoplasm and inhibits the replication of vesicular stomatitis virus (VSV), thereby conferring resistance to VSV infection. Unlike Mx2, Mx1 is localized to the nucleus where, upon induction by IFN-alpha/IFN-beta, it provides selective resistance to infection by the highly lethal H5N1 influenza virus. In humans, MxA and MxB function in a similar manner to Mx1 and Mx2, conferring resistance to specific target viruses. Mx3 is a rat-specific member of the myxovirus resistance protein family. |
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