- ￥880
- Bioss
- bs-24307P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-24307P |
| 英文名称 | PCSK1 Antibody Blocking Peptide |
| 中文名称 | NEC1封闭多肽 |
| 英文别名 | BDP; NEC 1; NEC1; NEC1_HUMAN; Neuroendocrine convertase 1; PC1; PC3; PCSK1; Prohormone convertase 1; Prohormone convertase 1/3; Prohormone convertase 3; Proprotein convertase 1; SPC3. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cancer Metabolism > Metabolic signaling pathway > Hormone biosynthesis Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Serine protease > Proprotein Convertases Metabolism > Pathways and Processes > Endocrine metabolism > Hormone biosynthesis Signal Transduction > Growth Factors/Hormones > Hormones |
| 亚细胞定位 | Cytoplasmic vesicle > secretory vesicle. Localized in the secretion granules. |
| 相似性 | Belongs to the peptidase S8 family. Furin subfamily. |
| 功能 | Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Jan 2014] |
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PCSK1 Antibody Blocking Peptide(bs-24307P)-500ug
￥880
