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- Bioss
- bs-0557P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-0557P |
| 英文名称 | Mfn1 Antibody Blocking Peptide |
| 中文名称 | 线粒体融合蛋白1封闭多肽 |
| 英文别名 | Mitofusin 1; Fzo homolog; MFN 1; Mitochondrial transmembrane GTPase Fzo 1; Mitochondrial transmembrane GTPase FZO 2; Mitochondrial transmembrane GTPase FZO1B; Mitofusin 1; Mitofusin1; Putative transmembrane GTPase; Transmembrane GTPase MFN1; MFN1_HUMAN; Mitofusin-1. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitophagy fission and fusion Neuroscience > Neurology process > Neurodegenerative disease > Parkinson's disease Signal Transduction > Second Messenger > Nucleotide Messenger > GTP Tags & Cell Markers > Subcellular Markers > Organelles > Mitochondria |
| 亚基 | Forms homomultimers and heteromultimers with MFN2. Multimerization, which is mediated by the second coiled coil region, may play an essential role in mitochondrion fusion. Participates in a high molecular weight multiprotein complex. Interacts with VAT1. |
| 亚细胞定位 | Cytoplasm and Mitochondrion outer membrane. |
| 组织特异性 | Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers. |
| 翻译后修饰 | Ubiquitinated by MARCH5. |
| 相似性 | Belongs to the mitofusin family. |
| 功能 | Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Mitofusin 1 (Mfn1) and mitofusin 2 (Mfn2) are homologs for the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins and are mediators of mitochondrial fusion. A GTPase domain is required for Mfn protein function but the molecular mechanisms of the GTPase-dependent reaction as well as the functional division of the two Mfn proteins are unknown. They are essential for embryonic development and may play a role in the pathobiology of obesity. Although the Mfn1 and Mfn2 genes are broadly expressed, they show different levels of expression in different tissues. Two Mfn1 transcripts are elevated in heart, while Mfn2 mRNA is abundantly expressed in heart and muscle tissue but present only at low levels in many other tissues. Mfn1 localizes to mitochondria and participates in at least two different high molecular weight protein complexes in a GTP-dependent manner. Purified recombinant Mfn1 exhibited approximately eightfold higher GTPase activity than Mfn2. |
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Mfn1 Antibody Blocking Peptide(bs-0557P)-500ug
￥880
