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- bs-0996P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-0996P |
| 英文名称 | EPHB2 Antibody Blocking Peptide |
| 中文名称 | 酪氨酸蛋白激酶受体B2封闭多肽 |
| 英文别名 | Tyrosine-protein kinase receptor EPH-3; Developmentally regulated EPH related tyrosine kinase; ELK related protein tyrosine kinase; EPH tyrosine kinase 3; Ephrin type B receptor 2; Receptor protein-tyrosine kinase HEK5; Tyrosine protein kinase receptor QEK 5; Tyrosine-protein kinase TYRO5; Renal carcinoma antigen NY-REN-47; EPHB2; EPH receptor B2; EPHT3; HEK5; TYRO5; Cek5; Drt; Nuk; ETECK; Qek5; Sek3; ERK; Tyro5; Prkm5; EK5; Eph receptor B2; EPH-like kinase 5; EPHB2; EPHB2_HUMAN; Ephrin type-B receptor 2; hEK5; Nuk; Prkm 5; Sek 3; Tyro 5; Tyrosine protein kinase receptor CEK 5; Tyrosine protein kinase receptor EPH 3; Tyrosine-protein kinase receptor EPH-3. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Angiogenesis > Ephrins > Eph Receptors Neuroscience > Cell Type Marker > Neuron marker > Growth Cone Neuroscience > Neurology process > Growth and Development > Axonal Guidance Proteins Neuroscience > Neurotransmission > Intracellular Signaling > Kinases Neuroscience > Neurotransmission > Receptors / Channels > Tyrosine Kinase Receptors Signal Transduction > Protein Phosphorylation > Tyrosine Kinases > Receptor Tyrosine Kinases |
| 亚基 | Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain). Interacts with ARHGEF15; mediates ARHGEF15 phosphorylation, ubiquitination and degradation by the proteasome. Interacts with AQP1; involved in endolymph production in the inner ear. |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite. |
| 组织特异性 | Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain. |
| 相似性 | Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 1 Eph LBD (Eph ligand-binding) domain. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain. Contains 1 SAM (sterile alpha motif) domain. |
| 功能 | Receptor for members of the ephrin-B family. Phosphorylates ARHGEF15, leading to its ubiquitination and degradation by the proteasome which promotes EFNB1-dependent synapse formation. Can function in aspects of retinal ganglion cell axon guidance to the optic disk even when lacking its tyrosine kinase domain. Acts as a tumor suppressor. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015] |
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EPHB2 Antibody Blocking Peptide(bs-0996P)-500ug
￥880
