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- Bioss
- bs-11394P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-11394P |
| 英文名称 | Utrophin Antibody Blocking Peptide |
| 中文名称 | 肌营养不良蛋白相关蛋白1封闭多肽 |
| 英文别名 | DMDL; DRP 1; DRP; DRP-1; DRP1; Dystrophin like protein; Dystrophin related protein 1; Dystrophin related protein; Dystrophin-related protein 1; FLJ23678; UTRN; UTRO_HUMAN; Utrophin (homologous to dystrophin); Utrophin |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Cell Type Marker > Neuron marker > Synapse marker Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Actin Binding Proteins |
| 亚基 | Interacts with the syntrophins SNTA1; SNTB1 and SNTB2. Interacts with SYNM. Interacts (via its WWW and ZZ domains) with DAG1 (via the PPXY motif of betaDAG1); the interaction is inhibited by the tyrosine phosphorylation of the PPXY motif of DAG1. |
| 亚细胞定位 | Cell junction > synapse > postsynaptic cell membrane. Cytoplasm > cytoskeleton. Neuromuscular junction. |
| 组织特异性 | Muscle. |
| 相似性 | Contains 2 CH (calponin-homology) domains. Contains 20 spectrin repeats. Contains 1 WW domain. Contains 1 ZZ-type zinc finger. |
| 功能 | May play a role in anchoring the cytoskeleton to the plasma membrane. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Dystrophin and utrophin are related structural, Actin-binding proteins that are involved in anchoring the cytoskeleton to the plasma membrane. Dystrophin is the protein product of the Duchenne/Becker muscular dystrophy gene. Dystrophin expression is found in muscle and brain tissues, where it is localized to the inner surface of the plasma membrane. It has been speculated that alternative splicing of the carboxy terminus allows dystrophin to interact with a variety of proteins. Research has shown that the loss of dystrophin-associated proteins in Duchenne afflicted muscle is due to the absence of dystrophin rather than to muscle degradation and that the lack of dystrophin results in the loss of linkage between the cytoskeleton and the extracellular matrix. Evidence suggests that the upregulation of utrophin can reduce the dystrophic pathology. |
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Utrophin Antibody Blocking Peptide(bs-11394P)-500ug
￥880
