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- bs-20028P
- 2025年10月16日
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500ug
| 产品编号 | bs-20028P |
| 英文名称 | MTA3 Antibody Blocking Peptide |
| 中文名称 | 转移相关蛋白MTA3封闭多肽 |
| 英文别名 | 1110002J22Rik; fj99h01; KIAA1266; Metastasis associated 1 family, member 3; Metastasis associated 3; Metastasis associated family, member 3; Metastasis associated gene 3; Metastasis associated gene family, member 3; Metastasis associated protein MTA3; Metastasis-associated protein MTA3; MGC56396; MGC77410; mKIAA1266; mta1; Mta3; MTA3 metastasis associated 1 family, member 3; Mta3 metastasis associated 3; MTA3_HUMAN; wu:fj99h01; zgc:56396. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Signal transduction > Nuclear signaling > Nuclear hormone receptors > Estrogen Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Acetylation > HDACs > Class I Epigenetics and Nuclear Signaling > Chromatin Remodeling > Mi-2 Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Estrogen Epigenetics and Nuclear Signaling > Transcription > Co-factors Epigenetics and Nuclear Signaling > Transcription > Other factors Signal Transduction > Growth Factors/Hormones > Hormones Signal Transduction > Signaling Pathway > Nuclear Signaling > Nuclear Hormone Receptors > Estrogen |
| 亚细胞定位 | Nucleus. |
| 相似性 | Contains 1 BAH domain. Contains 1 ELM2 domain. Contains 1 GATA-type zinc finger. Contains 1 SANT domain. |
| 功能 | Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Metastasis-associated protein 3 (MTA3) is a subunit of the Mi-2/NuRD transcriptional corepressor complex. MTA3 and the Mi-2/NuRD complex mediate repression of Snail in breast cancer cells where MTA3 works to maintain a differentiated, epithelial status. The protein is involved in gene expression regulation by covalent modifications of histone proteins. There are two known isoforms of MTA3, a short and a long form. The short isoform binds to ER and sequesters it to the cytoplasm and betters non-genomic responses, whereas the long form is found in the nucleus. MTA3 is widely expressed in with highest expression in brain, adrenal glands, ovaries and virgin mammary glands. It has been found to be expressed in higher levels in tumors than in adjacent normal tissue in the same individual. |
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