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- Bioss
- bs-20016P
- 2025年10月16日
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500ug
| 产品编号 | bs-20016P |
| 英文名称 | NLRC4 Antibody Blocking Peptide |
| 中文名称 | 凋亡加强结构域蛋白12封闭多肽 |
| 英文别名 | LRR; CARD 12; CARD; CARD LRR and NACHT containing protein 1; CARD LRR and NACHT containing protein; CARD12; Caspase recruitment domain containing protein 12; Caspase recruitment domain-containing protein 12; CLAN 1; CLAN A; CLAN; CLAN B; CLAN C; CLAN D; Clan protein; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR 2.1; CLR2.1; ICE protease activating factor; Ice protease-activating factor; Ipaf; NLR family CARD domain containing 4; NLR family CARD domain-containing protein 4; NLRC 4; NLRC4; NLRC4_HUMAN; and NACHT-containing protein. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell Death > Apoptosis > Metabolism Cell Biology > Apoptosis > Intracellular > Caspases etc > CARD Family Epigenetics and Nuclear Signaling > Cell cycle > Apoptosis > Nuclear Immunology > Innate Immunity > Macrophage / Inflamm. Metabolism > Pathways and Processes > Metabolism processes > Apoptosis |
| 亚基 | Component of the NLRC4 inflammasome. Homooligomer. Interacts with ASC, pro-caspase-1, NOD2, BCL10 and NALP1 (NAC) by CARD-CARD interaction. Interacts with EIF2AK2/PKR. |
| 亚细胞定位 | Cytoplasm. Cytoplasm, cytosol. Note=Cytoplasmic filaments. |
| 组织特异性 | Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain. |
| 翻译后修饰 | Phosphorylated at Ser-533 following infection of macrophages with S.typhimurium (Salmonella). Phosphorylation is essential for NLRC4 inflammasome function to promote caspase-1 activation and pyroptosis. PRKCD phosphorylates Ser-533 in vitro. |
| 相似性 | Contains 1 CARD domain.
Contains 14 LRR (leucine-rich) repeats. Contains 1 NACHT domain. |
| 功能 | Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | NLR family CARD domain-containing protein 4 is a protein that in humans is encoded by the NLRC4 gene. NLRC4 is best associated with triggering formation of the inflammasome. Unlike NLRP3, certain inflammasome-dependent functions of NLRC4 may be carried out independently of the inflammasome scaffold ASC. Human Ced4 homologs include APAF1, NOD1 (CARD4), and NOD2 (CARD15). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis. |
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NLRC4 Antibody Blocking Peptide(bs-20016P)-500ug
￥880
