- ￥880
- Bioss
- bs-16732P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-16732P |
| 英文名称 | Trim30a Antibody Blocking Peptide |
| 中文名称 | TRIM30蛋白封闭多肽 |
| 英文别名 | Down regulatory protein of interleukin 2 receptor; Rpt 1; Rpt1; TR30A_MOUSE; Trim 30; Tripartite motif containing 30; Tripartite motif-containing protein 30A. |
| 纯化方法 | HPLC |
| 亚基 | Homomultimer. Interacts with NR2C2/TAK1, TAB2 and TAB3. Does not interact with NLRP3, NLRC4 or TAB1. |
| 亚细胞定位 | Nuclear |
| 组织特异性 | Highly expressed in spleen and lymph nodes (at protein level). |
| 相似性 | Contains 1 B box-type zinc finger. Contains 1 B30.2/SPRY domain. Contains 1 RING-type zinc finger. |
| 功能 | Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Trans acting factor that regulates gene expression of interleukin 2 receptor alpha chain and of Human immunodeficiency virus type 1. May affect IL2R alpha and HIV 1 expression through cis acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. |
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Trim30a Antibody Blocking Peptide(bs-16732P)-500ug
￥880
