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- Bioss
- bs-0523P
- 2025年10月16日
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500ug
| 产品编号 | bs-0523P |
| 英文名称 | Sox2 Antibody Blocking Peptide |
| 中文名称 | 胚胎干细胞关键蛋白封闭多肽 |
| 英文别名 | transcriptional factor SOX2; ANOP3; cb236; Delta EF2a; lcc; MCOPS3; MGC148683; MGC2413; RGD1565646; Sex determining region Y box 2; Sex determining region Y-box 2; SOX 2; SRY (sex determining region Y) box 2; SRY box containing gene 2; SRY related HMG box 2; SRY related HMG box gene 2; SRY-box 2; ysb; SOX2_HUMAN; Transcription factor SOX-2; SOX2_HUMAN. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Developmental Biology > Embryogenesis > Embryonic stem cells > Surface molecules Developmental Biology > Reproduction > Germ cell markers Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper > Leucine Zipper Epigenetics and Nuclear Signaling > Transcription > Domain Families > HMG Box Neuroscience > Cell Type Marker > Neural Stem Cell marker Neuroscience > Neurology process > Neural Signal Transduction Neuroscience > Neurology process > Neurogenesis Stem Cells > Embryonic Stem Cells > Intracellular Stem Cells > Germline Stem Cells > Embryonic Germ Cells |
| 亚基 | Interacts with ZSCAN10. Interacts with SOX3 and FGFR1. |
| 亚细胞定位 | Nucleus. |
| 翻译后修饰 | Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation. |
| 相似性 | Contains 1 HMG box DNA-binding domain. |
| 功能 | Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]. |
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Sox2 Antibody Blocking Peptide(bs-0523P)-500ug
￥880
