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- bs-0657P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-0657P |
| 英文名称 | MRP1 Antibody Blocking Peptide |
| 中文名称 | 多药耐药相关蛋白1封闭多肽 |
| 英文别名 | Multidrug Resistanec-Associated Protein 1; ABC 29; ABC29; ABCC 1; ABCC; ABCC1; ATP binding cassette sub family C (CFTR/MRP) member 1; ATP binding cassette sub-family C member 1; DKFZp686N04233; DKFZp781G125; GS X; GSX; Leukotriene C(4) transporter; LTC4 transporter; MRP 1; MRP; Multidrug resistance associated protein 1; Multidrug resistance protein; Multiple drug resistance associated protein; Multiple drug resistance protein 1; MRP1_HUMAN. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cancer Metabolism > Metabolic signaling pathway > Hormone biosynthesis Cancer > Drug resistance > MRP-related proteins Cardiovascular > Atherosclerosis > Hypertension > Sodium/ion transport Cardiovascular > Blood > Blood Pressure regulation Metabolism > Pathways and Processes > Endocrine metabolism > Hormone biosynthesis Metabolism > Pathways and Processes > Metabolic signaling pathways > Drug metabolism Metabolism > Types of disease > Heart disease Signal Transduction > Metabolism > Drug metabolism Signal Transduction > Metabolism > Plasma Membrane > Channels |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Lung, testis and peripheral blood mononuclear cells. |
| 相似性 | Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains. |
| 功能 | Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012] |
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MRP1 Antibody Blocking Peptide(bs-0657P)-500ug
￥880
