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- Bioss
- bs-1316P
- 2025年10月16日
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500ug
| 产品编号 | bs-1316P |
| 英文名称 | PDGF-BB Antibody Blocking Peptide |
| 中文名称 | 血小板源性生长因子BB封闭多肽 |
| 英文别名 | PDGF BB; PDGF-BB; platelet derived growth factor-BB; Becaplermin; C sis; FLJ12858; Oncogene SIS; PDG B chain; PDGB; PDGF 2; PDGF B; PDGF B chain; PDGF2; PDGFB; PDGFB/COL1A1 fusion gene; Platelet derived growth factor 2; Platelet derived growth factor B chain; Platelet derived growth factor beta; Platelet derived growth factor beta polypeptide; Simian sarcoma viral (v sis) oncogene homolog; SIS; SSV; V sis platelet derived growth factor beta polypeptide. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cancer Metabolism > Response to hypoxia Cancer > Growth factors > PDGF Cardiovascular > Atherosclerosis > Vascular Inflammation > Inflammatory mediators Cardiovascular > Blood > Serum Proteins Developmental Biology > Organogenesis > Angiogenesis and vasculogenesis Metabolism > Pathways and Processes > Metabolism processes > Hypoxia Metabolism > Types of disease > Heart disease Signal Transduction > Growth Factors/Hormones > PDGF |
| 亚基 | Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFA; antiparallel disulfide-linked dimer. The PDGFB homodimer interacts with PDGFRA and PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with XLKD1. |
| 亚细胞定位 | Secreted. Note=Released by platelets upon wounding. |
| 组织特异性 | Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung. |
| 相似性 | Belongs to the PDGF/VEGF growth factor family. |
| 功能 | Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heal the wound. [SUBUNIT] Antiparallel disulfide-linked dimer of nonidentical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor. Belongs to the PDGF/VEGF growth factor family. |
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PDGF-BB Antibody Blocking Peptide(bs-1316P)-500ug
￥880
