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- bs-0740P
- 2025年10月16日
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500ug
| 产品编号 | bs-0740P |
| 英文名称 | CDKN2A/p16-INK4a/P16 Antibody Blocking Peptide |
| 中文名称 | 抑癌基因p16封闭多肽 |
| 英文别名 | cyclin-dependent kinase inhibitor 2A; CDK4I; p16-INK4; p16-INK4a; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A, isoform 1; Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4); cell cycle inhibitor; cyclin-dependent kinase inhibitor 2a p16Ink4a; cell cycle regulator; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor 2A, isoform 2; Cdkn2a; Arf; INK4A; MTS1; p16; p16Cdkn2a; p19ARF; CD2A2_HUMAN. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell cycle > Cell cycle inhibitors > Ink4 Cancer > Oncoproteins/suppressors > Tumor suppressors > p53 pathway Cell Biology > Cell Cycle > Cell Cycle Inhibitors > Ink4 Epigenetics and Nuclear Signaling > Cell cycle > Cell Cycle Inhibitors > Ink4 Epigenetics and Nuclear Signaling > Transcription > Cancer susceptibility > Tumor Suppressors |
| 亚基 | Heterodimer with CDK4 or CDK6. Predominant p16 complexes contained CDK6. Interacts (isoforms 1,2 and 4) with CDK4 (both 'T-172'-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase activity. Interacts with ISCO2. |
| 亚细胞定位 | Cytoplasm. Nucleus. |
| 组织特异性 | Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific. |
| 翻译后修饰 | Ubiquitinated in normal cells by TRIP12 via the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination at the N-terminus, regardeless of the absence of lysine residues. Ubiquitination leads to its degradation. In cancer cells, however, TRIP12 is located in a different cell compartment, preventing ubiquitination and degradation. |
| 相似性 | Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. Contains 4 ANK repeats. |
| 功能 | Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]. |
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CDKN2A/p16-INK4a/P16 Antibody Blocking Peptide(bs-0740P)-500ug
￥880
