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- Bioss
- bs-11347P
- 2025年10月16日
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500ug
| 产品编号 | bs-11347P |
| 英文名称 | GRID2IP Antibody Blocking Peptide |
| 中文名称 | 谷氨酸受体δ2/GluR-δ2封闭多肽 |
| 英文别名 | Delphilin; delta 2 interacting protein 1; Grid Delta2; GluR-Delta 2 Glutamate receptor; GRD2I_HUMAN; grid2ip; ionotropic. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Cell Type Marker > Neuron marker > Synapse marker Neuroscience > Neurotransmission > Receptors / Channels > Ligand-Gated Ion Channels > More Channels Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Actin Binding Proteins |
| 亚细胞定位 | Cell junction > synapse > postsynaptic cell membrane. |
| 相似性 | Contains 1 FH2 (formin homology 2) domain. Contains 2 PDZ (DHR) domains. |
| 功能 | Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Grid2ip is a postsynaptic scaffolding protein that contains one formin homology 2 (FH2) domain and two PDZ (postsynaptic density-95/discs-large/ZO-1) domains. Expressed in Purkinje cells of the cerebellum and localizing specifically to parallel fiber synapses, Grid2ip interacts with the C-terminus of GluR-Delta 2 and, via this interaction, links GluR-Delta 2 with various signaling molecules and the Actin cytoskeleton. GluR-Delta 2 is a glutamate receptor with an important role in motor learning, cerebellar wiring and synaptic plasticity. Due to alternative splicing events, three Grid2ip isoforms exist, namely L-delphilin, S-delphilin (or delphilin-Alpha) and delphilin-Beta. Each isoform exhibits individual expression patterns and protein interactions. Isoform 2, delphilin-Alpha, is palmytoylated, a modification that is essential for the enhanced expression of GluR-Delta 2 on the cell surface. This modification of delphilin-Alpha also mediates the accumulation of delphilin-Alpha in dendritic spines. |
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GRID2IP Antibody Blocking Peptide(bs-11347P)-500ug
￥880
