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- Bioss
- bs-11323P
- 2025年10月16日
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500ug
| 产品编号 | bs-11323P |
| 英文名称 | CSPG5 Antibody Blocking Peptide |
| 中文名称 | 跨膜硫酸软骨素蛋白聚糖C封闭多肽 |
| 英文别名 | Acidic leucine rich EGF like domain containing brain protein; Acidic leucine-rich EGF-like domain-containing brain protein; Caleb; CSPG5_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Cell Type Marker > Neuron marker > Soma marker Neuroscience > Cell Type Marker > Neuron marker > Synapse marker Neuroscience > Neurology process > Neurogenesis Neuroscience > Neurology process > Neuroregeneration > Neuroregeneration Stem Cells > Neural Stem Cells > Intracellular |
| 亚基 | Binds TNR and probably TNC (By similarity). Interacts with ERBB3 and GOPC. |
| 亚细胞定位 | Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus membrane. In neurons, localizes to synaptic junctions (By similarity). Also detected in the endoplasmic reticulum and the Golgi (By similarity). Partially enriched in lipid rafts. |
| 组织特异性 | Restricted to brain (at protein level). |
| 翻译后修饰 | O-glycosylated; contains chondroitin sulfate glycans. Part-time proteoglycan, expressed in part as a proteoglycan exhibiting chondroitin sulfate glycans and in part as a non-proteoglycan form. The relative amount of both forms depends on tissues and tissues maturation. Phosphorylated; in intracellular and extracellular parts. |
| 相似性 | Contains 1 EGF-like domain. |
| 功能 | May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Neuroglycan C is a brain-specific chondroitin sulfate proteoglycan (CSPG) implicated in the proliferation of neural stem and progenitor cells. Neuro-glycan C is a single-pass membrane protein that can manifest as a part-time proteoglycan depending on the tissue expressing it. In its proteoglycan form, Neuroglycan C exhibits chondroitin sulfate glycans and functions as a receptor for midkine, a growth factor that binds heparin, to affect cytoskeletal changes. By means of ectodomain shedding, the ectodomain of Neuroglycan C is able to enhance neurite outgrowth from neurons. Neurite growth stimulation is affected by both an EGF-like and an acidic amino acid domain found on the shed ectodomain. Both domains instigate neurite growth, however, these domains exhibit differing functionality as to number of neurites produced and neuron types stimulated. |
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CSPG5 Antibody Blocking Peptide(bs-11323P)-500ug
￥880
