CHIT1 Antibody Blocking Peptide(bs-13904P)-500ug

CHIT1 Antibody Blocking Peptid

e(bs-13904P)-500ug
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  • bs-13904P
  • 2025年10月16日
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      500ug

    产品编号bs-13904P
    英文名称CHIT1 Antibody Blocking Peptide
    中文名称几丁质酶1封闭多肽
    英文别名CHI3; CHIT; CHIT1; CHIT1_HUMAN; CHITD; Chitinase 1; Chitinase 1 (chitotriosidase); Chitinase-1; Chitotriosidase; Chitotriosidase-1; EC 3.2.1.14; FLJ00314; MGC125322; Plasma methylumbelliferyl tetra N acetylchitotetraoside hydrolase.
    纯化方法HPLC
    研究领域

    Immunology > Innate Immunity > Macrophage / Inflamm.

    亚细胞定位Secreted. Lysosome. A small proportion is lysosomal.
    组织特异性Detected in spleen. Secreted by cultured macrophages.
    相似性Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.
    Contains 1 chitin-binding type-2 domain.
    功能Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]

     

     

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