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500ug
| 产品编号 | bs-13904P |
| 英文名称 | CHIT1 Antibody Blocking Peptide |
| 中文名称 | 几丁质酶1封闭多肽 |
| 英文别名 | CHI3; CHIT; CHIT1; CHIT1_HUMAN; CHITD; Chitinase 1; Chitinase 1 (chitotriosidase); Chitinase-1; Chitotriosidase; Chitotriosidase-1; EC 3.2.1.14; FLJ00314; MGC125322; Plasma methylumbelliferyl tetra N acetylchitotetraoside hydrolase. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Innate Immunity > Macrophage / Inflamm. |
| 亚细胞定位 | Secreted. Lysosome. A small proportion is lysosomal. |
| 组织特异性 | Detected in spleen. Secreted by cultured macrophages. |
| 相似性 | Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. Contains 1 chitin-binding type-2 domain. |
| 功能 | Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012] |
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CHIT1 Antibody Blocking Peptide(bs-13904P)-500ug
¥880







