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- Bioss
- bs-12638P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-12638P |
| 英文名称 | SMG5 Antibody Blocking Peptide |
| 中文名称 | SMG5蛋白封闭多肽 |
| 英文别名 | EST1-like protein B; EST1B; LPTS-interacting protein; LPTS-RP1; nonsense mediated mRNA decay factor. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing |
| 亚基 | Interacts with TERT, PPP2CA and SMG1. Part of a complex that contains SMG1, SMG5, SMG7, PPP2CA, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated UPF1. Not detected in complexes that contain unphosphorylated UPF1. |
| 亚细胞定位 | Cytoplasmic and Nuclear. |
| 组织特异性 | Ubiquitous. |
| 相似性 | Contains 1 PINc domain. |
| 功能 | Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi et al., 2003 [PubMed 14636577]).[supplied by OMIM, Mar 2008] |
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SMG5 Antibody Blocking Peptide(bs-12638P)-500ug
￥880
