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- bs-41439P
- 2025年10月16日
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| 规格： | 100ug | 产品价格： | ￥1880.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥5680.0 |
| 规格： | 20ug | 产品价格： | ￥580.0 |
| 产品编号 | bs-41439P |
| 英文名称 | Recombinant human COX2 protein, N-His |
| 中文名称 | 重组人环氧合酶2/前列腺素内过氧化物合成酶2蛋白 |
| 英文别名 | PTGS2; COX 2; COX-2; Cyclooxygenase; Cyclooxygenase2; Cyclooxygenase-2; COX2; hCox 2; PGG/HS; PGH synthase 2; PGHS 2; PGHS2; PHS 2; PHS II; PHS2; Prostaglandin endoperoxide synthase 2; Prostaglandin G/H synthase 2 precursor; Prostaglandin G/H synthase and cyclooxygenase; Prostaglandin G/H synthase 2; Prostaglandin H2 synthase 2; TIS10II; PGH2_HUMAN; |
| 性状 | Liquid |
| 纯化方法 | AC |
| 理论分子量 | 35 |
| 实际分子量 | 35kDa |
| 浓度 | ＞0.5 mg/ml |
| 储存液 | 20mM Tris-HCl (pH8.0) 0.02% Proclin300 with 10% Glycerol. |
| 研究领域 | Cancer > Cancer Metabolism > Metabolic signaling pathway > Hormone biosynthesis Cancer > Tumor biomarkers Cardiovascular > Atherosclerosis > Lipoprotein metabolism Cardiovascular > Blood > Platelets Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Cholesterol Metabolism Immunology > Innate Immunity > Macrophage / Inflamm. Metabolism > Pathways and Processes > Endocrine metabolism > Hormone biosynthesis Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Cholesterol Metabolism Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipoprotein metabolism Metabolism > Types of disease > Heart disease Signal Transduction > Signaling Pathway > Lipid Signaling > Prostaglandins |
| 亚基 | Homodimer. |
| 亚细胞定位 | Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Post-translational modifications : S-nitrosylation by NOS2 (iNOS) activates enzme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-561. |
| 翻译后修饰 | S-nitrosylation by NOS2 (iNOS) activates enzme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-561. |
| 相似性 | Belongs to the prostaglandin G/H synthase family. Contains 1 EGF-like domain. |
| 功能 | Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009] |
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