CES3 Antibody Blocking Peptide(bs-13869P)-500ug

CES3 Antibody Blocking Peptide

(bs-13869P)-500ug
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  • bs-13869P
  • 2025年10月16日
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      500ug

    产品编号bs-13869P
    英文名称CES3 Antibody Blocking Peptide
    中文名称羧酸酯酶3封闭多肽
    英文别名Carboxylesterase 3; CES 3; Ces3; ES3; EST3_HUMAN; FLJ21736; Liver carboxylesterase 31 homolog.
    纯化方法HPLC
    研究领域

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Drug metabolism

    Signal Transduction > Metabolism > Drug metabolism

    亚细胞定位Endoplasmic reticulum lumen.
    组织特异性Expressed in liver, colon and small intestine.
    翻译后修饰N-glycosylated.
    相似性Belongs to the type-B carboxylesterase/lipase family.
    功能Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as Cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010]

     

     

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