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- bs-12607P
- 2025年10月16日
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500ug
| 产品编号 | bs-12607P |
| 英文名称 | PDZD3 Antibody Blocking Peptide |
| 中文名称 | PDZ结构域PDZK3蛋白封闭多肽 |
| 英文别名 | IKEPP; Intestinal and kidney enriched PDZ protein; Intestinal and kidney-enriched PDZ protein; Na(+)/H(+) exchange regulatory cofactor NHE-RF4; Na/Pi cotransporter C terminal associated protein 2; Na/Pi cotransporter C-terminal-associated protein 2; NaPi-Cap2; Natrium-phosphate cotransporter IIa C-terminal-associated protein 2; NHERF-4; NHERF4; NHRF4_HUMAN; PDZ domain containing 2; PDZ domain containing 3; PDZ domain containing protein 2; PDZ domain-containing protein 2; PDZ domain-containing protein 3; PDZD 3; Pdzd3; PDZK2; Protein DLNB27; Sodium-hydrogen exchanger regulatory factor 4. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Second Messenger > Nucleotide Messenger > cGMP |
| 亚细胞定位 | Cell membrane. Cytoplasm. Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells. |
| 组织特异性 | Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal muscle or cells of hematopoietic origin. |
| 相似性 | Contains 4 PDZ (DHR) domains. |
| 功能 | Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008] |
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PDZD3 Antibody Blocking Peptide(bs-12607P)-500ug
￥880
