- ￥880
- Bioss
- bs-11299P
- 2025年10月16日
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500ug
| 产品编号 | bs-11299P |
| 英文名称 | NAB2 Antibody Blocking Peptide |
| 中文名称 | EGR1结合蛋白2封闭多肽 |
| 英文别名 | EGR 1 binding protein 2; EGR-1-binding protein 2; EGR1 binding protein 2; MADER; Melanoma associated delayed early response protein; Melanoma-associated delayed early response protein; MGC75085; Nab 2; nab2; NAB2_HUMAN; NGFI A binding protein 2 (EGR1 binding protein 2); NGFI A binding protein 2; NGFI-A-binding protein 2; Protein MADER. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Co-factors Epigenetics and Nuclear Signaling > Transcription > Other factors Neuroscience > Neurology process > Neurogenesis |
| 亚基 | Homomultimers may associate with EGR1 bound to DNA (By similarity). |
| 亚细胞定位 | Nucleus. Isoform 2 is not localized to the nucleus. |
| 组织特异性 | Widely expressed at low levels. Highly expressed in melanoma cell lines. |
| 翻译后修饰 | Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain. |
| 相似性 | Belongs to the NAB family. |
| 功能 | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Transcriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (for NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2 are corepressors of EGF-1/NGFI-A. Both NAB1 and NAB2 contain an amino terminal NAB conserved domain 1 (NCB1), which is required for binding NGFI-A, and a carboxy terminal NCD2 domain, which is responsible for the repressor function of NAB proteins. NAB2 is principally localized in the nucleus and may play a role in the downregulation of NGFI-A activity as well as in controlling fundamental processes such as cell division, differentiation and apoptosis. NAB2 localizes to chromosome 12q13.3-14.1, a region that is rearranged in several solid tumors, lipomas, and liposarcomas. |
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NAB2 Antibody Blocking Peptide(bs-11299P)-500ug
￥880
