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- bs-10681P
- 2025年10月16日
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500ug
| 产品编号 | bs-10681P |
| 英文名称 | phospho-TYRO3 (Tyr681) Antibody Blocking Peptide |
| 中文名称 | 磷酸化受体酪氨酸激酶封闭多肽 |
| 英文别名 | TYRO3(phospho Tyr681); TYRO3(phospho Y681); Brt; BYK; DTK; RSE; SKY; Tif; TYRO3; TYRO3_HUMAN; Tyrosine-protein kinase DTK; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Cell Adhesion Proteins > Membrane Proteins Neuroscience > Neurotransmission > Intracellular Signaling > Kinases Signal Transduction > Protein Phosphorylation > Tyrosine Kinases |
| 亚基 | Monomer and homodimer. Interacts (via N-terminus) with extracellular ligands TULP1 and GAS6. Interacts with PIK3R1; this interaction increases PI3-kinase activity. |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. |
| 组织特异性 | Abundant in the brain and lower levels in other tissues. |
| 翻译后修饰 | Autophosphorylated. |
| 相似性 | Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. Contains 2 fibronectin type-III domains. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain. |
| 功能 | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010] |
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phospho-TYRO3 (Tyr681) Antibody Blocking Peptide(bs-10681P)-500ug
￥1080
