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- Bioss
- bs-23983P
- 2025年10月16日
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500ug
| 产品编号 | bs-23983P |
| 英文名称 | GATA4 Antibody Blocking Peptide |
| 中文名称 | GATA结合蛋白4封闭多肽 |
| 英文别名 | GATA binding factor 4; GATA 4; GATA4; GATA-4; Transcription factor GATA-4; GATA-binding factor 4; Gata4; GATA4_HUMAN; GATA-binding factor 4. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Oncoproteins/suppressors > Tumor suppressors Cardiovascular > Cardiovascular Markers Cardiovascular > Cardiovascular Markers > Cell Markers > Cardiomyocytes Cardiovascular > Heart > Hypertrophy > Transcription factors Developmental Biology > Lineage specification > Endoderm Epigenetics and Nuclear Signaling > Transcription > Domain Families > Zinc Finger Stem Cells > Lineage Markers > Endoderm Stem Cells > Mesenchymal Stem Cells > Myogenesis |
| 亚基 | Interacts with ZNF260. Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with NFATC4 and LMCD1. Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes. |
| 亚细胞定位 | Nucleus. |
| 翻译后修饰 | Methylation at Lys-300 attenuates transcriptional activity. |
| 相似性 | Contains 2 GATA-type zinc fingers. |
| 功能 | Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | GATA4 is a 46 kDa member of the GATA family of zinc finger containing transcription factors that is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene expression in cardiac and smooth muscle cell types. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1 / 2, and weakly through JNK or p38 MAPKs. |
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GATA4 Antibody Blocking Peptide(bs-23983P)-500ug
￥880
