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- bs-12569P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-12569P |
| 英文名称 | phospho-SLC4A1 (Tyr21) Antibody Blocking Peptide |
| 中文名称 | 磷酸化红细胞阴离子交换蛋白1封闭多肽 |
| 英文别名 | Band 3 (phospho Y21); p-Band 3 (phospho Y21); Solute carrier family 4 anion exchanger member 1; Solute carrier family 4 member 1; AE 1; AE1; Anion exchange protein 1; Anion exchanger 1; B3AT_HUMAN; Band 3; Band 3 anion transport protein; BND3; CD233; DI; Diego blood group; EMPB3; EPB3; Erythrocyte membrane protein band 3; Erythroid anion exchange protein; FR antibod; Froese blood group; RTA1A; SLC4A1; Solute carrier family 4 member 1; SW antibody; Swann blood group; Waldner blood group; WD antibody; WD1; WR antibody; Wright blood group. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Blood Cardiovascular > Blood > Blood Cell Antigens > RBC Antigens |
| 亚基 | A dimer in solution, it spans the membrane asymmetrically and appears to be tetrameric. Interacts (via cytoplasmic N-terminus domain) with ANK1 (via N-terminus ANK repeats). |
| 亚细胞定位 | Membrane; Multi-pass membrane protein. |
| 组织特异性 | Erythrocytes. |
| 翻译后修饰 | Phosphorylated on Tyr-8 and Tyr-21 most likely by SYK. PP1-resistant phosphorylation that precedes Tyr-359 and Tyr-904 phosphorylation. Phosphorylated on Tyr-359 and Tyr-904 most likely by LYN. PP1-inhibited phosphorylation that follows Tyr-8 and Tyr-21 phosphorylation. |
| 相似性 | Belongs to the anion exchanger (TC 2.A.31) family. |
| 功能 | Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Band 3, also designated AE1, is an erythrocyte membrane glycoprotein that contributes to cell stuctural integrity and mediates exchange of chloride and bicarbonate across the phospholipid bilayer. The diverse functions of the approximately 900 amino acid protein are mediated by two distinct domains. The amino terminal domain, also known as cdb3 for cytoplasmic domain of erthrocyte membrane band 3, acts as an attachment site for the erythrocyte skeleton by binding ankyrin. The carboxy-terminal, membrane-associated domain carries out exchange transport of anions. Degradation of band 3 can generate an aging antigen known as senescent cell antigen, or SCA, which is expressed on old cells and marks them for removal by the immune system. An isoform of band 3, which lacks the first 65 amino acids and does not bind ankryin, is expressed in kidney. |
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phospho-SLC4A1 (Tyr21) Antibody Blocking Peptide(bs-12569P)-500ug
￥1080
