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- Bioss
- bs-2479P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-2479P |
| 英文名称 | CCL14 Antibody Blocking Peptide |
| 中文名称 | 嗜酸粒细胞趋化蛋白14封闭多肽 |
| 英文别名 | CAPER; CCL14; CCL14_HUMAN; chemokine (C-C motif) ligand 14; Chemokine CC-1/CC-3; chemokine CC1; chemokine CC3; chemokine HCC1; chemokine HCC3; CKb1; Coactivator of activating protein 1 and estrogen receptors; Coactivator of AP1 and ERs; HCC-1(1-74); HCC-1(9-74); HCC-1/HCC-3; HCC1; HEMOFILTRATE CC CHEMOKINE 1; Hepatocellular carcinoma protein 1; MCIF; NCC-2; NCC2; RNA binding region (RNP1 RRM) containing 2; RNA binding region containing protein 2; RNPC2; SCYA14; SCYL2; Small-inducible cytokine A14; Splicing factor CC1.3; Splicing factor CC1.4; Splicing factor HCC1; SY14; Transcription coactivator CAPER. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Innate Immunity > Chemokines > Beta Chemokines (CC) Metabolism > Pathways and Processes > Cofactors, Vitamins / minerals > Vitamins / minerals Signal Transduction > Metabolism > Vitamins / Minerals |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma. |
| 翻译后修饰 | The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood. HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated; the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids. |
| 相似性 | Belongs to the intercrine beta (chemokine CC) family. |
| 功能 | Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249. [provided by RefSeq]. |
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CCL14 Antibody Blocking Peptide(bs-2479P)-500ug
￥880
