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- Bioss
- Bovine IgM / APC(bs-0327P-APC)-100ul
- 2025年10月16日
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100ul
| 产品编号 | bs-0327P-APC |
| 英文名称 | Bovine IgM / APC |
| 中文名称 | APC标记牛IgM |
| 英文别名 | Bovine Immunoglobulin M/APC |
| 中文别名 | 荧光素APC标记牛IgM |
| 性状 | Liquid |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存条件 | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences. |
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文献和实验三句话读懂一篇 CNS：肥胖导致脱发；逆转慢性心脏病；杂交土豆问世...
-1Wang, W., Shao, F., Yang, X. et al. METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N6-methyladenosine-dependent YTHDF binding. Nat Commun 12, 3803 (2021). https://doi.org/10.1038/s41467-021-23501-5Yang, Q., Xue, SL
细胞激活；④通过转基因表达CD40L的成纤维细胞。也能刺激B细胞；⑤CD40或CD40L基因敲除的小鼠，抗体产生形成的缺陷类似人类的X性联高IgM血症，患者只产生了IgM，而无其他类别的抗体，也无生发中心，抗感染能力明显下降。 CD40与其配体CD401。的结合，导致CD40分子的寡聚化，使胞质中的TNF受体相关因子(TNF receptor-associ-atedfactor，TRAF)与CD40的胞内结构域结合。TRAF参与启动的酶催化级联反应，最终导致转录因子NFκB和AP-1等活化。
expression studiesAvailable in the following LABORATORY:CAMR Centre for Applied Microbiology & Research (ECACC, Salisbury, Wiltshire)Ham's F12 + 2mM Glutamine + 10% Fetal Bovine Serum (FBS). Split confluent cultures 1:4 to 1:10 i.e. seeding at 1-2x10,000
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