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- Bioss
- bs-11382R-FITC
- 2025年10月15日
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100ul
| 产品编号 | bs-11382R-FITC |
| 英文名称 | A4GNT Rabbit pAb, FITC conjugated |
| 中文名称 | FITC标记的α1,4-N-乙酰葡糖胺转移酶α4Gn-T抗体 |
| 英文别名 | 4-N-acetylglucosaminyltransferase; A4GCT_HUMAN; A4GNT; alpha 1 4 N acetylglucosaminyltransferase; alpha-1; alpha4GnT; EC 2.4.1.; MGC149493. |
| 产品应用 | ICC/IF=1:50-200, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human A4GNT |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚细胞定位 | Golgi apparatus membrane. |
| 组织特异性 | Detected in stomach and pancreas. |
| 相似性 | Belongs to the glycosyltransferase 32 family. |
| 功能 | Necessary for the synthesis of type III mucin. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Alpha 1,4-N-acetylflucosaminyltransferase (Alpha4Gn-T) mediates the biosynthesis of mucin type glycoprotein (O-glycan). Alpha4Gn-T acts as the key enzyme for the formation of the unique glycan GlcNAcalpha1-4Galbeta1-R, and most efficiently transfers N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. Alpha4Gn-T is a single-pass type II membrane protein associated with the Golgi apparatus and contains the conserved DXD motif involved in catalytic activity. It is expressed in stomach and pancreas, as well as in gastric cancer cells. Alpha4Gn-T is not expressed in peripheral blood cells, making it a useful biomarker for pancreatic cancer. Alpha4Gn-T and Mucin 6 expression is upregulated in the gastric mucosa of H.pylori infected patients, which suggest the involvement of ?Gn-T in defense against H. pylori infection. |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:50-200} |
| {IF} | {1:100-500} |
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Fluorochrome Absorption and Emission
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