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GLIPR1 Antibody Blocking Pepti

de(bs-22736P)-500ug
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  • 2025年10月16日
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    产品编号bs-22736P
    英文名称GLIPR1 Antibody Blocking Peptide
    中文名称脑胶质瘤发病机制相关蛋白1封闭多肽
    英文别名ALKN2972; GLIPR1-like protein 1; MGC26856; PRO7434; UNQ2972/PRO7434; GLIPR; RTVP1; GliPR 1; Protein RTVP-1; Glioma pathogenesis-related protein 1; GLIP1_HUMAN.
    纯化方法HPLC
    研究领域

    Cancer > Cell Death > Apoptosis

    Cancer > Invasion/microenvironment > Apoptosis

    Cancer > Oncoproteins/suppressors > Tumor suppressors > p53 pathway

    Cell Biology > Apoptosis > Intracellular > p53 Pathway

    亚细胞定位Single-pass membrane protein.
    组织特异性According to PubMed:8973356, it is ubiquitously expressed with high levels in lung and kidney and low levels in heart and liver. Highly expressed in cell lines derived from nervous system tumors arising from glia, low or absent in non-glial-derived nervous system tumor cell lines. Also found in fetal kidney. According to PubMed:7607567 it is expressed only in brain tumor glioblastoma multiforme/astrocytoma and not in other nervous system tumors or normal fetal or adult tissues.
    相似性Belongs to the CRISP family.
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

     

     

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